Praziquantel ameliorates CCl4 -induced liver fibrosis in mice by inhibiting TGF-β/Smad signalling via up-regulating Smad7 in hepatic stellate cells.
作者： Jinfeng Liu , Delong Kong , Jingfan Qiu , Yanci Xie , Zhongkui Lu
DOI: 10.1111/BPH.14831
关键词: SMAD 、 Gene knockdown 、 Praziquantel 、 In vivo 、 Chemistry 、 Hepatic stellate cell 、 Cell activation 、 Cancer research 、 In vitro 、 Cell culture
摘要: … well as a mouse model of CCl 4 -induced liver fibrosis in vivo, the present study was designed to test the hypothesis that praziquantel ameliorated liver fibrosis by inhibiting TGF-β/Smad …
sci-hub.se 参考文章(48)
Nega Berhe, Svein G. Gundersen, Bjørn Myrvang, Reversibility of Schistosomal Periportal Thickening/Fibrosis after Praziquantel Therapy: A Twenty-Six Month Follow-up Study in Ethiopia American Journal of Tropical Medicine and Hygiene. ,vol. 78, pp. 228- 234 ,(2008) , 10.4269/AJTMH.2008.78.228
Santiago Trainor-Moss, Francisca Mutapi, Schistosomiasis therapeutics: whats in the pipeline? Expert Review of Clinical Pharmacology. ,vol. 9, pp. 157- 160 ,(2016) , 10.1586/17512433.2015.1102051
Xing He, Jun Xie, Dongmei Zhang, Qin Su, Xue Sai, Ruipu Bai, Chao Chen, Xufeng Luo, Guangping Gao, Weiqing Pan, Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways Hepatology. ,vol. 61, pp. 2008- 2017 ,(2015) , 10.1002/HEP.27671
Ling Yang, Sayaka Inokuchi, Yoon Seok Roh, Jingyi Song, Rohit Loomba, Eek Joong Park, Ekihiro Seki, Transforming Growth Factor–β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1 Gastroenterology. ,vol. 144, pp. 1042- 1054 ,(2013) , 10.1053/J.GASTRO.2013.01.056
Yi-xin Huang, Yong-liang Xu, Chuan-xin Yu, Hong-jun Li, Xu-ren Yin, Tie-sheng Wang, Wei Wang, You-sheng Liang, Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice. Parasitology Research. ,vol. 109, pp. 1453- 1459 ,(2011) , 10.1007/S00436-011-2485-2
Kamal Ishak, Amelia Baptista, Leonardo Bianchi, Francesco Callea, Jan De Groote, Fred Gudat, Helmut Denk, Valeer Desmet, Gerhard Korb, Roderick N.M. MacSween, M.James Phillips, Bernard G. Portmann, Hemming Poulsen, Peter J. Scheuer, Martin Schmid, Heribert Thaler, Histological grading and staging of chronic hepatitis. Journal of Hepatology. ,vol. 22, pp. 696- 699 ,(1995) , 10.1016/0168-8278(95)80226-6
Dominique Thabut, Vijay Shah, Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension? Journal of Hepatology. ,vol. 53, pp. 976- 980 ,(2010) , 10.1016/J.JHEP.2010.07.004
Fabio Ribeiro, Rômulo Teixeira de Mello, Carlos Alberto Pereira Tavares, John Robert Kusel, Paulo Marcos Zech Coelho, Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Revista Do Instituto De Medicina Tropical De Sao Paulo. ,vol. 46, pp. 231- 233 ,(2004) , 10.1590/S0036-46652004000400010
Somchai Pinlaor, Yusuke Hiraku, Puangrat Yongvanit, Saeko Tada-Oikawa, Ning Ma, Porntip Pinlaor, Paiboon Sithithaworn, Banchob Sripa, Mariko Murata, Shinji Oikawa, Shosuke Kawanishi, iNOS-dependent DNA damagevia NF-κB expression in hamsters infected withOpisthorchis viverrini and its suppression by the antihelminthic drug praziquantel International Journal of Cancer. ,vol. 119, pp. 1067- 1072 ,(2006) , 10.1002/IJC.21893
Giovanni Latella, Antonella Vetuschi, Roberta Sferra, Valentina Catitti, Angela D'Angelo, Giuliana Zanninelli, Kathleen C. Flanders, Eugenio Gaudio, Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Liver International. ,vol. 29, pp. 997- 1009 ,(2009) , 10.1111/J.1478-3231.2009.02011.X