A Review of Rodent Models of Type 2 Diabetic Skeletal Fragility

摘要: Evidence indicating that adult type 2 diabetes (T2D) is associated with increased fracture risk continues to mount. Unlike osteoporosis, diabetic fractures are obesity and normal high bone mineral density, two factors typically reduced risk. Animal models will likely play a critical role in efforts identify the underlying mechanisms of skeletal fragility T2D develop preventative treatments. In this review we critically examine ability current rodent mimic characteristics human T2D. We report although there numerous T2D, few have undergone thorough assessments metabolism strength. Further, find many available limitations for studies because onset often prior maturation mass low, contrast what seen humans. There an urgent need characterize phenotype existing new more closely effects adult-onset