Scanned ion beam therapy for prostate carcinoma: Comparison of single plan treatment and daily plan-adapted treatment.

摘要: Intensity-modulated particle therapy (IMPT) for tumors showing interfraction motion is a topic of current research. The purpose this work to compare three treatment strategies IMPT determine potential advantages and disadvantages ion prostate cancer therapy. Simulations strategies, conventional one-plan radiotherapy (ConvRT), image-guided (IGRT), online adaptive (ART) were performed employing dataset 10 prostate patients with six CT scans taken at one week intervals. simulation results, using geometric margin concept (7–2 mm) as well patient-specific internal target volume definitions analyzed by coverage exposure critical structures on single fraction dose distributions. All led clinically acceptable in exhibiting small (mean displacement < 4 mm), but IGRT especially ART significant sparing the rectum. In 20 % patients, exceeded 4 mm causing insufficient ConvRT (V95mean = 0.86, range 0.63–0.99) = 0.91, 0.68–1.00), while maintained coverage. demands consideration rectal replanning large motion.