Zwitterionic phthalocyanine zinc (II) synthesis, and photodynamic activity comparison with nonionic and cationic phthalocyanine
作者： Li Gui , Quanquan Zhang , Yue Wang , Kelong Fang , Ao Wang
DOI: 10.1016/J.INOCHE.2016.11.007
关键词: Solubility 、 Photochemistry 、 Zinc 、 Cationic polymerization 、 Reactive oxygen species 、 Phthalocyanine 、 Combinatorial chemistry 、 Photodynamic therapy 、 Chemistry
摘要: Zwitterionic structures were helpful for solubility, cellular uptake and activity for many drugs. But few researches about the influence of zwitterionic structures on phthalocyanine were reported. So, in this work, we design and synthesis a zwitterionic zinc (II) phthalocyanines (ZnPcs). And its solubility, photochemical and photodynamic activity to cancer cells was investigated. Furthermore, these properties of other two ZnPcs, nonionic and cationic ZnPcs with same major structure, were also researched simultaneously. Comparative studies …
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