作者: Dammika P. Manage , Duncan G. Elliott , Christopher J. Backhouse
关键词: Millimeter 、 Nanotechnology 、 Polymer 、 Computer science 、 Matrix (chemical analysis) 、 Microfluidics 、 Microelectronics 、 Lab-on-a-chip 、 Pcr cloning 、 Scale separation
摘要: Electrophoresis is a powerful method that has seen wide range of applications, often in automated genetic diagnostic instruments require the use replaceable sieving matrix. The power and simplicity electrophoresis as an analysis technique would be ideal for highly integrated low-cost systems if could implemented microfluidics on scale several mm. We demonstrate electrophoretic DNA with separation lengths small 2 mm resolution adequate PCR products, i.e. resolutions 10-20 base pairs. Such small-scale separations enable consisting microelectronics into single inexpensive package, thereby overcoming key challenge facing development lab chip technologies.