Racemic drug resolution: a comprehensive guide
作者： Sachin Mane
DOI: 10.1039/C6AY02015A
关键词: Drug 、 Enantiopure drug 、 High dosage 、 Enantiomer 、 Chemistry 、 Industrial scale 、 Biological activity 、 Resolution (mass spectrometry) 、 Enantiomeric excess 、 Organic chemistry 、 General Engineering 、 Analytical chemistry 、 General Chemical Engineering
摘要: The human body is amazingly chirally selective, and consequently enantiopure drugs are essential for treating disease. Nowadays, market approval of enantiopure drugs has increased exponentially whereas it has tremendously decreased for racemic and achiral drugs.
rsc.org
sci-hub.se 参考文章(262)
A. Grandeury, L. Renou, F. Dufour, S. Petit, G. Gouhier, G. Coquerel, Chiral resolution by crystallization of host-guest supramolecular complexes Journal of Thermal Analysis and Calorimetry. ,vol. 77, pp. 377- 390 ,(2004) , 10.1023/B:JTAN.0000038979.32555.58
Jeffrey B. Malick, Michael Williams, Drug Discovery and Development ,(1987)
Lushan Yu, Shengjia Wang, Su Zeng, Chiral mobile phase additives in HPLC enantioseparations. Methods of Molecular Biology. ,vol. 1985, pp. 221- 231 ,(2013) , 10.1007/978-1-62703-263-6_13
George D. Olsen, Herbert A. Wendel, James O. Livermore, Regina M. Leger, Robert K. Lynn, Nicholas Gerber, Clinical eftects and pharmacokinetics of racemic methadone and its optical isomers Clinical Pharmacology & Therapeutics. ,vol. 21, pp. 147- 157 ,(1977) , 10.1002/CPT1977212147
David J. Browning, Pharmacology of Chloroquine and Hydroxychloroquine Hydroxychloroquine and Chloroquine Retinopathy. pp. 35- 63 ,(2014) , 10.1007/978-1-4939-0597-3_2
B. Toussaint, Ph. Hubert, U.R. Tjaden, J. van der Greef, J. Crommen, Enantiomeric separation of clenbuterol by transient isotachophoresis-capillary zone electrophoresis-UV detection new optimization technique for transient isotachophoresis. Journal of Chromatography A. ,vol. 871, pp. 173- 180 ,(2000) , 10.1016/S0021-9673(99)00983-8
Myung-Ho Hyun, Development and Application of Crown Ether-based HPLC Chiral Stationary Phases Bulletin of The Korean Chemical Society. ,vol. 26, pp. 1153- 1163 ,(2005) , 10.5012/BKCS.2005.26.8.1153
M. Eichelbaum, Side effects and toxic reactions of chiral drugs: A clinical perspective Archives of Toxicology. ,vol. 17, pp. 514- 521 ,(1995) , 10.1007/978-3-642-79451-3_44
H.W. Yu, C.B. Ching, Modeling, Simulation and Operation Performance of a Simulated Moving Bed for Enantioseparation of Fluoxetine on New β-Cyclodextrin Columns Adsorption-journal of The International Adsorption Society. ,vol. 9, pp. 213- 223 ,(2003) , 10.1023/A:1024745732668
V G Manade, Lekha Pathak, P G Kerkar, Hiremath, Multicentric, clinical trial of S-Amlodipine 2.5 mg versus Amlodipine 5 mg in the treatment of mild to moderate hypertension--a randomized, double-blind clinical trial. Journal of Association of Physicians of India. ,vol. 52, pp. 197- 202 ,(2004)