Drug Discovery and Development
作者： Jeffrey B. Malick , Michael Williams
DOI:
关键词:
摘要: The process of drug discovery involves a melding many disciplines and interests, transcending the relatively simple identifying an active compound in test tube. novel chemical entity that modulates some aspect cell or tissue function is but first step development process. Once shown to be selective efficacious, must also free toxicity, bioavailable, marketable before it can considered therapeutic entity.
springer.com
amazon.com
montclair.edu
openlibrary.org参考文章(58)
D. Jack, M. J. Daly, R. T. Brittain, B. J. Price, R. Stables, J. Bradshaw, J. W. Clitherow, Ranitidine (AH 19065): a new potent, selective histamine H2-receptor antagonist [proceedings]. British Journal of Pharmacology. ,vol. 66, ,(1979)
Robert G. Denkewalter, Max Tishler, Drug Research — Whence and Whither Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques. ,vol. 10, pp. 11- 31 ,(1966) , 10.1007/978-3-0348-7059-7_1
Najam A. Sharif, Excitatory Amino Acid Receptors Springer, Boston, MA. pp. 239- 259 ,(1984) , 10.1007/978-1-4684-4568-8_9
Elliott Richelson, Jeffrey B. Malick, S. J. Enna, Antidepressants : neurochemical, behavioral, and clinical perspectives Raven Press. ,(1981)
John G. Topliss, Quantitative structure-activity relationships of drugs Academic Press. ,(1983)
Michael Williams, David C. U'Prichard, Chapter 28. Drug Discovery at the Molecular Level: A Decade of Radioligand Binding in Retrospect Annual Reports in Medicinal Chemistry. ,vol. 19, pp. 283- 292 ,(1984) , 10.1016/S0065-7743(08)60704-6
Michael Williams, S.J. Enna, Chapter 21: The Receptor: From Concept to Function Annual Reports in Medicinal Chemistry. ,vol. 21, pp. 211- 235 ,(1986) , 10.1016/S0065-7743(08)61131-8
Robert Kanigel, Apprentice to Genius: The Making of a Scientific Dynasty ,(1986)
S M Strittmatter, D R Lynch, S H Snyder, [3H]guanidinoethylmercaptosuccinic acid binding to tissue homogenates. Selective labeling of enkephalin convertase. Journal of Biological Chemistry. ,vol. 259, pp. 11812- 11817 ,(1984) , 10.1016/S0021-9258(20)71284-6
J. Mansel Thomas, The Primrose path Gower. pp. 19- ,(1954)