Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O -3-hexose derivative
作者： Kevin J Saliba , Sanjeev Krishna , Kiaran Kirk
DOI: 10.1016/J.FEBSLET.2004.06.032
关键词: Glycolysis 、 Hexose 、 Hexose transport 、 Xenopus 、 Glucose transporter 、 Adenosine triphosphate 、 Biology 、 Intracellular pH 、 Transporter 、 Biochemistry
摘要: An O-3-hexose derivative, shown previously to inhibit a malaria parasite hexose transporter expressed in Xenopus oocytes as well suppress the multiplication of parasites, both vitro and vivo, was here block uptake sugars into isolated blood-stage parasites. This led decline ATP levels loss intracellular pH control. The results are consistent with those obtained cloned transporter. They support notion that mediates glucose intraerythrocytic provide further for view it is suitable antimalarial drug target.
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