Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.
作者： J. C. Eissenberg , T. C. James , D. M. Foster-Hartnett , T. Hartnett , V. Ngan
关键词: Position-effect variegation 、 Heterochromatin protein 1 、 Heterochromatin 、 Genetics 、 Point mutation 、 Drosophila melanogaster 、 Position effect 、 Transition (genetics) 、 Variegation 、 Biology
摘要: Abstract We report here that a point mutation in the gene which encodes heterochromatin-specific nonhistone chromosomal protein HP-1 Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, G-to-A transition at first nucleotide last intron, causes missplicing mRNA. This suggests proteins play central role heterochromatic position effects.
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