Extracranial blood flow, pain and tenderness in migraine. Clinical and experimental studies.

摘要: Migraine pain has traditionally been ascribed to dilatation of primarily extracranial arteries. Such has, however, not demonstrated so far. Studies microcirculation reveal no major hyperperfusion or ischemia in the temporal muscle subcutaneous tissue region during attacks migraine. However, a reduction orthostatic reactivity arterioles was observed on side headache. Increased tenderness pericranial myofascial tissues is migraine attacks, particularly tension muscles other hand constant finding and are induced by experimentally increased masseter muscles. Extracranial may, be intramuscular injections hypertonic saline potassium chloride as well endogenous substances like bradykinin with 5-hydroxytryptamine substance P. The arteries structures both supplied unmyelinated trigeminal sensory nerve fibers containing variety neuropeptides which released attacks. Axonal reflexes between neighbouring referred mechanisms may account for