Bacterial Community Dynamics across the Gastrointestinal Tracts of Dairy Calves during Preweaning Development

摘要: Microbial communities play critical roles in the gastrointestinal tracts (GIT) of preruminant calves by influencing performance and health. However, little is known about establishment microbial calf GIT or their dynamics during development. In this study, next-generation sequencing was used to assess changes bacterial rumen, jejunum, cecum, colon 26 crossbred at four developmental stages (7, 28, 49, 63 days old). Alpha diversity differed among regions with lowest evenness whereas no alpha were observed across stage. Beta analysis showed both region age effects, low numbers operational taxonomic units (OTUs) shared between within a given group ages region. Taxonomic revealed that several taxa coexisted but abundances considerably age. As aged, we lower such as Bacteroides, Parabacteroides, Paraprevotella higher Bulleidia Succiniclasticum rumen. The jejunum also displayed increases Clostridiaceae Turicibacter older calves. gut, Lactobacillus, Blautia, Faecalibacterium decreased S24-7, Paraprevotella, Prevotella increased aged. These data support model whereby early successive colonization bacteria occurs provides insights into temporal microbiota dairy preweaning development.IMPORTANCE ruminants, cows, house complex contribute overall health ability produce milk. For example, rumen converts feed usable nutrients, while jejunal access protein. Thus, establishing properly functioning productivity adult cows. establishment, maintenance, life. evaluated development show they are highly variable on life before transitioning stable community. Understanding has implications for ensuring proper will aid efforts develop strategies improving downstream production.