Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma

摘要: A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, recurring lung lesion after 5 months, and metastasis right thigh months salvage chemotherapy. All four were pseudoeuploid showed identical chromosomal abnormalities: translocation chromosomes #6 one chromosome #11 involved, resulting 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint is region to which oncogene c-myb has been localized, at known fragile possibly oncogenic site, suggesting that translocations this case may have played crucial role development of malignancy.