Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment
作者： J. M. Castro-Lopes , I. Tavares , T. R. Tölle , A. Coimbra
DOI: 10.1016/0304-3959(94)90094-9
关键词: Capsaicin 、 Spinal cord 、 Neonatal capsaicin 、 Endocrinology 、 Hindlimb 、 Peripheral Neurectomy 、 GABAergic 、 Anesthesia 、 Carrageenan 、 Inflammation 、 Internal medicine 、 Medicine
摘要: Abstract An increase in the number of γ-aminobutyric acid (GABA)-immunorcactive cells is reported superficial dorsal horn rat spinal cord upon unilateral inflammation hind foot caused by subcutaneous carrageenan injection. The rise GABAergic was restricted to ipsilateral horn, reaching a peak value 23.4% over contralateral side 4 days after Sciatic neurectomy or neonatal capsaicin treatment prevented this effect. These findings suggest that GABA up-regulated noxious inflow conveyed unmyelinated C fibers from inflamed tissues.
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