Resuscitation at birth and cognition at 8 years of age: a cohort study

摘要: Summary Background Mild cerebral injury might cause subtle defects in cognitive function that are only detectable as the child grows older. Our aim was to determine whether infants receiving resuscitation after birth, but with no symptoms of encephalopathy, have reduced intelligence quotient (IQ) scores childhood. Methods Three groups were selected from Avon Longitudinal Study Parents and Children: who resuscitated at birth asymptomatic for encephalopathy had further neonatal care (n=815), those (n=58), reference group not resuscitated, (n=10 609). Cognitive assessed a mean age 8·6 years (SD 0·33); low IQ score defined less than 80. obtained 5953 children shortened version Weschler scale (WISC-III), remaining 5529 non-responders. All did complete all parts test, therefore multiplied values comparable full-scale test available 5887 children. Results adjusted clinical social covariates. Chained equations used impute missing Findings In main analysis 8 (n=5887), increased risk recorded both (odds ratio 1·65 [95% CI 1·13–2·43]) (6·22 [1·57–24·65]). However, population larger attributable fraction an be need 3·4% (95% 0·5–6·3) 1·2% (0·2–2·2) developed encephalopathy. Interpretation Infants score, even if they remained healthy during period. Resuscitated result proportion adults IQs do develop neurological consistent Funding Wellcome Trust.