Substituted heterocyclic compounds with CXCR3 antagonist activity

摘要: A compound having the general structure shown in Formula 1: or a salt, solvate ester of pharmaceutically acceptable thereof, wherein: G is selected from group consisting H, hydroxyl, alkoxy, R2R1N -, R2R1X-C (R145) (R1S) - and heteroaryl heterocyclenyl ring containing 5-membered at least one -C = N- moiety as part said being dihydroimidazole, imidazole, dihydrooxazole, oxazole, dihydrooxadiazole, oxadiazole, triazole tetrazole, wherein can be both (i) unsubstituted, (ii) optionally independently substituted on more carbon atoms with substituents R910, nitrogen R8, R8 R9 identical different; L N CR4 OZ; R1 R2 are absent present, if present each alkyl, alkenyl, carbonyl, cycloalkyl, cycloalkenyl, alkylaryl, arylalkyl, aryl, amino, alkylamino, amidinyl , carboxamido, cyano, urea, -NoCH, NCN, (CH2) qOH, qOR31, qNH2, qNHR31, qN (R31) 2, ( CH2) qC (= O) NHR31, qSO2R31, qNHSO2R31, qSO2NHR31, S) (H) -N -S (O) 2 C -alkyl, 2N S (alkyl) 2aryl, NH2, -heteroaryl, heterocyclyl, heterocyclenyl; alternatively when X N, taken together form (NH2) 2; R3 -H, -Cl -CH3 R4 moieties same different, aralkyl, -CN, CF3, haloalkyl, halogen, hydroxyalkyl, CH- (R31), (R30) -OR30, -SO2 R31; R6 H O, heteroaryl, heterocyclyl qNSO2R31 QSO) 2NHR31; -NH2 CH2CH3 R10 CH3, -CH2 CH2 CH3 R11 residues R12 -H D phenyl pyridinyl, unsubstituted 1-5 R20 40; halogen amino. R21 alkynyl, alquiltiocarboxi, alkylheteroaryl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, aminoalkyl, amidinyl, aralkyl aralkenyl, aralkoxy, aralkoxycarbonyl, aralkylthio, aroyl, aryloxy, formyl, guanidinyl, heteroalkyl, heterocyclenyl, hydroxamate, nitro, trifluoromethoxy, (CH2 ) q-NH2, qNSO2R31, qS2NHR31, -alquinilC 2OR31, R30, NR30) NHR30, NOH) NOR31) OR 30, R31, -NHC OR31, NCN) SO2 (R30), R30) -OC -SR30, -SO2N -OSO2 OSi 3; Y c