Effect of ethanol on the binding of warfarin enantiomers to human serum albumin
作者： Akitoshi Tatsumi , Muneo Kadobayashi , Seigo Iwakawa
DOI: 10.1248/BPB.30.826
关键词: Albumin 、 Enantiomer 、 Plasma protein binding 、 Ethanol 、 Ultrafiltration (renal) 、 Serum albumin 、 Human serum albumin 、 Chromatography 、 Drug interaction 、 Biochemistry 、 Chemistry
摘要: Ethanol is widely used as a pharmaceutical excipient for the solubilization of many hydrophobic drugs injections. However, there are only few studies about drug interaction with excipients in body after injection. In this study, effect ethanol (500 mM) or several alcohols on stereoselective binding warfarin enantiomers to fatty acid-free human serum albumin (HSA) proteins commercial preparations was investigated. An ultrafiltration method separation unbound enantiomers. By addition 1-propanol, fraction S-enantiomer decreased. On other hand, R-enantiomer increased by 1-propanol. Unbound fractions both S- and were decreased 2-propanol. various preparations, ethanol. The different effects among HSA observed.
sci-hub.se 参考文章(18)
Olof Borgå, Birgitta Borgå, Serum Protein Binding of Nonsteroidal Antiinflammatory Drugs: A Comparative Study Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 25, pp. 63- 77 ,(1997) , 10.1023/A:1025719827072
Harald Olsen, Anders Andersen, Arve Nordbø, Ulf E Kongsgaard, Ole P Børmer, Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro. BMC Clinical Pharmacology. ,vol. 4, pp. 4- 4 ,(2004) , 10.1186/1472-6904-4-4
Isabelle Petitpas, Ananyo A. Bhattacharya, Sue Twine, Malcolm East, Stephen Curry, Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin: ANATOMY OF DRUG SITE I * Journal of Biological Chemistry. ,vol. 276, pp. 22804- 22809 ,(2001) , 10.1074/JBC.M100575200
Bhagwant D Rege, Joseph P.Y Kao, James E Polli, Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers European Journal of Pharmaceutical Sciences. ,vol. 16, pp. 237- 246 ,(2002) , 10.1016/S0928-0987(02)00055-6
Chung-Eun Ha, Charles E. Petersen, David S. Park, Krishna Harohalli, Nadhipuram V. Bhagavan, Investigations of the effects of ethanol on warfarin binding to human serum albumin. Journal of Biomedical Science. ,vol. 7, pp. 114- 121 ,(2000) , 10.1007/BF02256617
Xiao Min He, Daniel C. Carter, Atomic structure and chemistry of human serum albumin. Nature. ,vol. 358, pp. 209- 215 ,(1992) , 10.1038/358209A0
Annette C. Moser, Charles Kingsbury, David S. Hage, Stability of warfarin solutions for drug-protein binding measurements: spectroscopic and chromatographic studies. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 41, pp. 1101- 1109 ,(2006) , 10.1016/J.JPBA.2006.02.012
Henrik Vorum, Bent Honoré, Influence of Fatty Acids on the Binding of Warfarin and Phenprocoumon to Human Serum Albumin with Relation to Anticoagulant Therapy Journal of Pharmacy and Pharmacology. ,vol. 48, pp. 870- 875 ,(2011) , 10.1111/J.2042-7158.1996.TB03990.X
George Wilding, Richard C. Feldhoff, Elliot S. Vesell, Concentration-dependent effects of fatty acids on warfarin binding to albumin Biochemical Pharmacology. ,vol. 26, pp. 1143- 1146 ,(1977) , 10.1016/0006-2952(77)90058-2
Isabelle Mignot, Nathalie Presle, Fran�oise Lapicque, Claudine Monot, R�mi Dropsy, Patrick Netter, Albumin binding sites for etodolac enantiomers. Chirality. ,vol. 8, pp. 271- 280 ,(1996) , 10.1002/(SICI)1520-636X(1996)8:3<271::AID-CHIR7>3.0.CO;2-K