Ferulic Acid against Cyclophosphamide-Induced Heart Toxicity in Mice by Inhibiting NF-κB Pathway

摘要: The purpose of the present study was to elucidate protective effects ferulic acid (FA) against cyclophosphamide- (CTX-) induced changes in mice. Forty-eight male ICR mice were divided into four groups. Control group intraperitoneally (i.p.) injected with 200 μL phosphate buffer saline (PBS). Model a single dose CTX (200 mg/kg). FA (50 mg/kg) and (100 mg/kg) groups (200 mg/kg) followed by intragastric treatment (50, 100 mg/kg) for 7 consecutive days. After 12 d, sacrificed analyze hematological, biochemical, histological parameters mechanism research. results indicated that significantly decreased serum levels alanine aminotransferase (ALT), aspartate (AST), creatine kinase (CK), lactate dehydrogenase (LDH), interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α) CTX-injected In addition, effectively reduced total numbers white blood cells (WBCs), red cells, platelets, hemoglobin content. also obviously attenuated heart tissues caused CTX. Moreover, Western blot demonstrated inhibited phosphorylations NF-κB signaling pathway CTX-stimulated cardiac tissues. conclusion, might be considered as an effective agent amelioration toxicity resulting from treatment.