Role of Glutamate in Alcohol Withdrawal Kindling

摘要: It is well known that continued excessive alcohol consumption can lead to the development of physiological dependence. When drinking abruptly terminated or substantially reduced in dependent individual, a characteristic withdrawal syndrome ensues. As with other central nervous system (CNS) depressants, symptoms associated cessation chronic use are opposite nature effects intoxication. Thus, clinical features include signs heightened autonomic activation (e.g., tachycardia, elevated blood pressure, diaphoresis, tremor), CNS hyperexcitability may culminate motor seizures, and, its most severe form, hallucinosis and delerium tremens (1–3). In addition physical withdrawal, constellation contributing psychological discomfort irritability, agitation, anxiety, dysphoria) constitute significant component (4–7). The overall intensity presumed reflect degree dependence developed during course use/abuse.