Upregulation of NMDA receptors in hippocampus and cortex in the pentylenetetrazol-induced "kindling" model of epilepsy.
作者： Antigoni Ekonomou , Fevronia Angelatou
关键词: Chemistry 、 Dentate gyrus 、 Epileptogenesis 、 Pentylenetetrazol 、 NMDA receptor 、 Kindling model 、 Kindling 、 Glutamate binding 、 Neuroscience 、 Hippocampus
摘要: "Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model temporal lobe epilepsy. At the present work we investigated contribution NMDA receptors in Pentylenetetrazol-induced "kindling" mouse brain, by using quantitative autoradiography and radioactive ligands [3H]MK801 [3H]L-glutamate (NMDA-sensitive component). One week after establishment kindling, small but significant increase well NMDA-sensitive [3H]glutamate binding was seen, being restricted to molecular layer (ML) dentate gyrus (DG) CA3 region hippocampus. These augmentations persisted one month kindling. A receptor also observed cortex-somatosensory acquisition kindled state. The upregulation seen DG hippocampus could be associated with kindling process this especially its maintenance phase, since it persists at long term, area-specific consistent electrophysiological data. cortex animals underlie hyperexcitability detected studies area.
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