Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma

作者: Ignacio Varela , Patrick Tarpey , Keiran Raine , Dachuan Huang , Choon Kiat Ong

DOI: 10.1038/NATURE09639

关键词: SWI/SNF complexExomeSETD2MutationPBRM1GeneticsBiologyChromatinCancer researchRegulation of gene expressionHistone H3

摘要: The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale …

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