Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis

摘要: Summary Background Although incrimination of the intestinal microbiota in pathogenesis IBD is widely accepted, few data are available about role specific bacteria. Potentially, Faecalibacterium prausnitzii, bacteria with anti-inflammatory properties, might be deficient ulcerative colitis (UC). Aim To quantify F. prausnitzii faecal UC patients remission and determine its relationship relapse. Methods A cross-sectional study included 116 remission, 29 first-degree relatives 31 healthy controls. A subset eighteen patients, recruited during first month underwent a 1-year follow-up. Total were measured by quantitative Real Time PCR (qPCR, copies/g). Calprotectin was determined as inflammatory index (μg/g). Results We found that reduced (median, IQR: 1.4 × 108, 5.1 × 107–4.5 × 108) (1.7 × 108, 9.3 × 107–5.1 × 108) vs. controls (6.5 × 108, 3.7 × 108–1.6 × 109, P < 0.0001). Moreover, low counts associated less than 12 months (8.0 × 107, 2.0 × 107–3.5 × 108 2.1 × 108, 1.0 × 108–7.9 × 108, P < 0.001) more 1 relapse/year 3.2 × 107–3.8 × 108 1.9 × 108, 6.8 × 107–6.0 × 108, P < 0.01). When followed up, increased steadily until reaching similar levels to those if persisted (2.9 × 108, 9.3 × 106–1.2 × 109; calprotectin: 76, 19–212), whereas it remained relapsed (2.2 × 108, 1.4 × 106–3.3 × 108; 1760, 844–3662 P < 0.05 controls). Conclusions Defective gut colonisation occurred their unaffected relatives. The recovery population after relapse maintenance clinical remission.