Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
作者： J G Jacobson , K L Ruffner , M Kosz-Vnenchak , C B Hwang , K K Wobbe
DOI: 10.1128/JVI.67.11.6903-6908.1993
关键词: Thymidine kinase 、 Thymidine 、 Virology 、 Herpes simplex virus 、 Herpesviridae 、 Lytic cycle 、 Virus 、 Trigeminal ganglion 、 Virus latency 、 Biology
摘要: From marker rescue, sequencing, transcript, and latency analyses of the thymidine kinase-negative herpes simplex virus mutant dlsactk studies using kinase inhibitor Ro 31-5140, we infer that virus-encoded is required in murine trigeminal ganglia for acute replication lytic gene expression, increasing numbers cells expressing latency-associated transcripts, reactivation from latent infection.
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