Long-term survival of a patient with giant cell glioblastoma. Case report.

摘要: ✓ The authors report on a patient who had undergone resection of left-sided temporal giant cell glioblastoma at the age 69 years and survived for more than 17 years. This man not postoperative radiotherapy or adjuvant chemotherapy. He died 86 without clinical evidence tumor recurrence. Histologically, lesion was characterized by highly pleomorphic cells (including bizarre multinucleated cells) with high mitotic activity, large necroses, prominent mononuclear infiltration. A point mutation in TP53 suppressor gene (c.524G>A: R175H) no epidermal growth factor receptor amplification were revealed molecular genetic analysis. No diagnostic chromosomal imbalances identified comparative genomic hybridization, although average ratio profile chromosome 10 indicated loss 10p15 subpopulation cells. is exceptional because resection, probably conjunction marked antitumor ...