Characterization of Glioblastomas in Young Adults

摘要: Most adult glioblastoma multiformes (GBMs) present in patients 45-70 years old; tumors occurring at the extremes of age spectrum are uncommon, and seldom studied. We hypothesized that young-adult GBMs would differ from elderly-adult pediatric GBMs. Cases were identified 1997 to 2005. Demographic histological features, MIB-1 TP53 immunohistochemical findings epidermal growth factor receptor (EGFR) amplification status by fluorescence situ hybridization compiled correlated with survival. Twenty-eight (74%) our 38 GBM had primary de novo tumors, two which occurred cancer syndromes. Two additional radiation-induced eight (21%) secondary Seven as long-term (>3 years) survivors. Six cases manifested unusual morphological including three epithelioid GBMs, one rhabdoid GBM, gliosarcoma small cell containing abundant, refractile, eosinophilic inclusions. index emerged most important prognosticator survival (P < 0.005). Although there was a trend between extent necrosis, expression, EGFR survival, none reached statistical significance. young adults more inhomogeneous tumor group than older show features overlap both