Clinicopathological characteristics and treatment of rhabdoid glioblastoma.
作者： Ranjith Babu , Jeffrey Hatef , Roger E. McLendon , Thomas J. Cummings , John H. Sampson
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摘要: Object Rhabdoid glioblastoma (GB) is an exceedingly rare tumor in which some of the cells possess rhabdoid features such as eccentric nuclei, abundant eosinophilic cytoplasm, and pseudopapillary formations. These tumors are exceptionally aggressive, leptomeningeal dissemination common. In 9 previously reported cases, longest survival was only months, with a median 17.8 weeks. The authors report clinicopathological characteristics 4 cases GB demonstrate utility intensive temozolomide adjuvant therapy these tumors. also review literature to provide most comprehensive understanding date. Methods A retrospective performed patients treated for at Duke University Medical Center between 2004 2012. One two experienced neuropathologists identified being GBs. Immunohistochemistry fluorescence situ hybridization analyses were all cases...
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