Atypical teratoid/rhabdoid tumor: short clinical description and insight into possible mechanism of the disease.

摘要: Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant typically appearing in childhood. Differentiation of AT/RT from other brain tumors extremely important because grim prognosis and necessity more aggressive treatment. On the hand, investigation essential for new therapeutic agents based on continuously developing knowledge development mechanisms. Most have been demonstrated to harbor chromosome 22 mutation region hSNF5/INI1 gene, whose protein product participates chromatin remodeling. Although presence this rather undisputable, additional molecular pathways underlying are poorly understood. Current paper discusses current views pathophysiology tumor.