Estrogen Sulfotransferase Is Expressed in Subcutaneous Adipose Tissue of Obese Humans in Association with TNF-α and SOCS3
作者： Rexford S. Ahima , Takara L. Stanley , Victor K. Khor , Markella V. Zanni , Steven K. Grinspoon
DOI: 10.1210/JC.2010-2903
关键词: Estrone 、 Glucose tolerance test 、 Estrogen Sulfotransferase 、 Biology 、 Internal medicine 、 Adipose tissue 、 Endocrinology 、 Adiponectin 、 Estrogen 、 Leptin 、 Insulin resistance
摘要: Context and Objective: Estrogen sulfotransferase (EST) catalyzes the inactivation of estrone estradiol in numerous tissues. Animal studies suggest that EST modulates glucose lipid metabolism adipose tissue, but it is unknown whether expressed human tissue and, if so, how its expression relates to features metabolic syndrome. Design Participants: Cross-sectional data from 16 obese men women with dysregulation were collected as part a larger randomized trial at an academic medical center. Outcome Measures: Participants underwent assessment body composition, oral tolerance testing, measurement serum hormones inflammatory markers, sc fat biopsy assess TNF-α, suppressor cytokine signaling 3 (SOCS3), leptin, adiponectin, EST. Results: was detectable both women. Log10 mRNA not significantly associated age, race, sex or menopausal status, c...
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