Factors influencing the development of metabolic bone disease in primary biliary cirrhosis.

摘要: The prevalence, type, and factors that may influence the development of bone disease in primary biliary cirrhosis, have been investigated 20 consecutive patients, who, addition to liver function tests mineral vitamin D metabolism studies, were submitted a transiliac biopsy after tetracycline double-labeling for quantitative histomorphometric examination. Intestinal calcium absorption was also assessed 16 patients. Seven patients (35%) had reduced volume considered osteoporotic. Three mineralization impairment, but did not criteria osteomalacia. Bone formation depressed 15 resorption low or normal 19 cases. Eroded surfaces all osteoporotic Duration cirrhosis significantly longer with osteoporosis (6.3 +/- 0.6 yr) than those without (2.6 0.6, p = 0.004). Moreover, more prevalent postmenopausal women, who intestinal malabsorption, which present 80% only 18% nonosteoporotic (p 0.03). Osteoporosis impairment unrelated severity cholestasis. 25-Hydroxyvitamin lower malabsorption. results this study indicate osteodystrophy is characterized mainly by "low-turnover" osteoporosis, related duration disease, condition,