Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer.

摘要: Tumours arising in BRCA1 mutation carriers and sporadic basal-like breast carcinomas have similar phenotypic, immunohistochemical clinical characteristics. SOX2 is an embryonic transcription factor located at chromosome 3q, a region frequently gained germline mutated tumours. The aim of the study was to establish whether sox2 expression related Two hundred twenty-six node-negative invasive were immunohistochemically analysed for oestrogen receptor (ER), progesterone (PR), CK5/6, EGFR, vimentin, HER2, ki67, p53 using tissue microarrays. considered phenotype if they ER/HER2-negative CK5/6 and/or EGFR-positive. Thirty cases this series (13.7%) displayed phenotype. Sox2 observed 16.7% significantly more expressed (43.3% basal-like, 10.6% luminal 13.3% HER2+ tumours, P<0.001). Moreover, showed statistically significant inverse association with ER PR (P=0.001 0.017, respectively) direct EGFR vimentin (P=0.022, 0.005 <0.001, respectively). preferentially tumours may play role defining their less differentiated/'stem cell' phenotypic