Hallmarks of 'BRCAness' in sporadic cancers
作者： Nicholas Turner , Andrew Tutt , Alan Ashworth
DOI: 10.1038/NRC1457
关键词: Biology 、 Gene 、 Cancer susceptibility 、 Genetics 、 Iniparib 、 Germline mutation 、 Cancer research 、 Oncology
摘要: Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, proteins encoded by these have distinct functions related DNA-repair processes. Emerging evidence indicates that processes are disrupted numerous mechanisms sporadic cancers. Collectively, there properties define 'BRCAness' — is, traits some cancers share with those occurring either BRCA1- or BRCA2-mutation carriers. These common might important implications for clinical management of
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