Familial Invasive Breast Cancers: Worse Outcome Related to BRCA1 Mutations
作者： Dominique Stoppa-Lyonnet , Yan Ansquer , Hélène Dreyfus , Chantal Gautier , Marion Gauthier-Villars
DOI: 10.1200/JCO.2000.18.24.4053
关键词: Tumor suppressor gene 、 Mutation 、 Cohort study 、 Medicine 、 Ovarian cancer 、 Cohort 、 Estrogen 、 Internal medicine 、 Pathology 、 Breast cancer 、 Oncology 、 Mammary gland
摘要: PURPOSE: Although all studies confirm that BRCA1 tumors are highly proliferative and poorly differentiated, their outcomes remain controversial. We propose to examine, through a cohort study, the pathologic characteristics, overall survival, local recurrence, metastasis-free intervals of 40 patients with breast cancer. PATIENTS AND METHODS: A 183 invasive cancer, treated at Institut Curie presenting familial history and/or ovarian were tested for germ-line mutation. Tumor characteristics clinical events extracted from our prospectively registered database. RESULTS: Forty mutations found among (22%). Median follow-up was 58 months. larger in size (P = .03), had higher rate grade 3 histoprognostic factors .002), frequency negative estrogen .003) progesterone receptors .002) compared non-BRCA1 tumors. Overall survival poore...
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