Ethnicity delineates different genetic pathways in malignant glioma.

摘要: In the United States and San Francisco Bay Area, whites are nearly twice as likely non-whites to develop brain cancer. To test whether prevalence types of alterations in p53 pathway tumor development may explain some this difference risk, we have analyzed status astrocytic gliomas from a population-based sample cases within our Area Adult Glioma Study. We identified mutations exons 5-8 using DNA extracted formalin-fixed paraffin-embedded tissue blocks 146 26 with glioma by PCR-single-strand conformation polymorphism direct sequencing. Tumor P53 protein (TP53) immunohistochemistry (IHC) available for 164 these showed that tumors 50% (13 26) 32% (44 138) contained intense IHC staining TP53, indicating persistence TP53 protein. Irrespective status, 42% (11 versus 13% (19 146) (age/gender-adjusted odds ratio, 5.7; 95% confidence interval, 2.2-15.1; P = 0.0004). Patients mutation-positive were also significantly younger than patients mutation-negative somewhat more be female. A higher proportion had transition mutations, but there similar proportions transversion non-whites. Whites stained intensely (78 82%, respectively). Because risk population, less those mutation suggests at common type gliomas, which do not contain mutations.