CYP1A1 variants and smoking‐related lung cancer in San Francisco bay area Latinos and African Americans

摘要: We examined CYP1A1 T6235C (M1) and A4889G (M2) polymorphisms in San Francisco Bay Area African Americans Latinos who were newly diagnosed with primary lung cancer from September 1998 to November 2002 age-gender-ethnicity frequency-matched controls. Owing mainly rapid mortality of cases, overall percentages cases genotyped 26% 32% for Americans, respectively. variants (104 278 controls) (226 551 controls). M1 M2 frequencies controls 0.23 0.02 0.38 0.29 Latinos. In Latinos, the inverse odds ratio (OR) 0.51 (95% CI = 0.32–0.81) variant genotype resulted an interaction smoking. Nonsmokers had a slight elevated OR (1.5; 0.59–3.7), but those less than 30 or more pack-year history 0.20 (0.06–0.70) 0.21 (0.06–0.81) times (about 1/5) expected if smoking independent risk factors. interactions similar magnitude that not statistically significant. Results very similar. Inverse smoking-associated might be causal, due undetected bias confounding, represent unique linkage disequilibrium between new locus this highly admixed population.