The Cancer Biology of Molecular Imaging

摘要: Cancer is a complex series of stepwise genetic alterations resulting in common biologic changes the transformed cells. Distinguishing features cancer include rapid proliferation cells, immortality, resistance to apoptosis, suppression proliferation, metastatic behavior, characteristic metabolism, and immunologic attack. cells recruit normal host tissues support growth tumor mass. Fibrocytes collagen producing provide structure for Endothelial are recruited form blood vessels. Tumor vessels have incomplete endothelium, making leaky. This allows large molecules leak into interstitium. The middle mass has few, if any, lymphatic combination vessel leakiness few lymphatics results an increased interstitial pressure tumor, it difficult chemotherapy diffuse