Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma
作者： Gideon Bollag , Peter Hirth , James Tsai , Jiazhong Zhang , Prabha N. Ibrahim
DOI: 10.1038/NATURE09454
关键词: Serine/Threonine-Protein Kinase B-Raf 、 Cancer research 、 Encorafenib 、 MAPK/ERK pathway 、 Kinase 、 Biology 、 Kinase activity 、 Melanoma 、 Proto-Oncogene Proteins B-raf 、 Vemurafenib
摘要: B-RAF is the most frequently mutated protein kinase in human cancers 1 . The finding that oncogenic mutations in BRAF are common in melanoma 2 , followed by the demonstration …
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