V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway
作者： C. A. Pratilas , B. S. Taylor , Q. Ye , A. Viale , C. Sander
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摘要: … In RTK-driven tumors, MEK inhibition relieves feedback inhibition of the pathway in vivo as well. In BT474 xenografts, pMEK levels were low, but induced after treatment with PD0325901…
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