PLGA-amoxicillin-loaded layer formed on anodized Ti alloy as a hybrid material for dental implant applications.

摘要: Abstract In this paper, the preparation of a functional hybrid coating loaded with drug (amoxicillin) on promising titanium alloy – Ti-15Mo is presented. The surface was anodized in solution bioactive compounds to obtain porous oxide layer favorable for MG-63 osteoblast-like cell adhesion. Then, poly(lactide-co-glycolide) (PLGA) amoxicillin formed using dip-coating technique cover layer, without filling all pores. morphology evaluated scanning electron microscopy supported by 3D Roughness Reconstruction software. treatment caused roughness increase up 1.71 μm. anodization process become slightly more hydrophilic; however, formation PLGA increased contact angle 96.5° ± 2.2°, respectively. After 4 weeks polymer degradation, registered signals 1H NMR spectrum were identical lactic acid (LAc), which confirms that degraded within short period time. concentration released into artificial saliva investigated high-performance liquid chromatography (HPLC) 12 h coatings immersion. During first hour degradation saliva, and (13 μg/ml) enough inhibit bacterial growth S. aureus epidermidis. These results confirmed agar plate diffusion method evaluation minimal inhibitory (MIC). cytocompatibility materials determined cells MG-63, viability (live/dead staining) also evaluated. showed influences cells' behavior during culture, especially few hours. influence type 7 days culture discussed paper. To best our knowledge, time fast-degrading has been deposited previously Ti surface. may find application as cytocompatible prevent adhesion long-term implant surfaces.