Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy.
作者： Carolyn J. Owen , Cynthia L. Toze , Anna Koochin , Donna L. Forrest , Clayton A. Smith
DOI: 10.1182/BLOOD-2008-05-156745
关键词: Transplantation 、 Blood Platelet Disorders 、 Lymphoproliferative disorders 、 Biology 、 Immunology 、 Myeloid Neoplasm 、 Platelet disorder 、 Hematopoietic stem cell transplantation 、 Myeloid leukemia 、 Patau's syndrome
摘要: … in AML 9 and by point mutations in MDS. An exception occurs in the most undifferentiated subtype of AML, FAB class M0, in which point mutations occur in approximately 20% of cases. …
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