Magnetic resonance imaging investigation of the mixing-segregation process in a pharmaceutical blender.
作者： N. Sommier , P. Porion , P. Evesque , B. Leclerc , P. Tchoreloff
DOI: 10.1016/S0378-5173(01)00718-9
关键词: Rotational speed 、 Particle size 、 Mixing (process engineering) 、 Powder bed 、 Particle 、 Nuclear magnetic resonance 、 Bead 、 Steady state 、 Chemistry 、 Analytical chemistry 、 Doping
摘要: Abstract Magnetic Resonance Imaging (MRI) was used to study the mixing process of binary mixtures free flowing sugar beads in a Turbula® mixer. In order make particles MRI-sensitive, some reference were doped with an organic oil. Doped and undoped mixed MRI non-destructively image particle bed for given number mixer rotations (NR), bead diameter ratio (R=dref/di) rotation speed (V). All results quantified on basis analysis characterise degree mixing. Studies showed that identical size, complete after 30 rotations, whereas different size (R=2.8) segregated steady state obtained nearly 10 rotations. Experiments revealed segregation appeared as soon R=0.9. Moreover, lower speed, more final was. It filling level greater than 80%, dead regions centre powder bed. conclusion, when are non-cohesive, blender perfectly mixes but occurs just few
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