Latest technologies for the enhancement of antibody affinity
作者： Kim L. Wark , Peter J. Hudson
DOI: 10.1016/J.ADDR.2006.01.025
关键词: Core protein 、 Pharmaceutical technology 、 Biology 、 Molecular biology 、 Mutagenesis (molecular biology technique) 、 Computational biology 、 Antibody affinity 、 Protein engineering 、 Human health
摘要: … , mutation and selection of high affinity antibodies that provide a paradigm for … antibody format, binding kinetics also dictates an antibody's potency. Antibody affinity refers to the binding …
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Lydia Blaise, Anita Wehnert, Mieke P.G. Steukers, Twan van den Beucken, Hennie R. Hoogenboom, Simon E. Hufton, Construction and diversification of yeast cell surface displayed libraries by yeast mating: application to the affinity maturation of Fab antibody fragments. Gene. ,vol. 342, pp. 211- 218 ,(2004) , 10.1016/J.GENE.2004.08.014
Christian Fermér, Irma Andersson, Karin Nilsson, Olle Nilsson, Specificity rescue and affinity maturation of a low-affinity IgM antibody against pro-gastrin-releasing peptide using phage display and DNA shuffling. Tumor Biology. ,vol. 25, pp. 7- 13 ,(2004) , 10.1159/000077717
N. C. Chien, V. A. Roberts, A. M. Giusti, M. D. Scharff, E. D. Getzoff, Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 5532- 5536 ,(1989) , 10.1073/PNAS.86.14.5532
Twan van den Beucken, Henk Pieters, Mieke Steukers, Marcel van der Vaart, Robert Charles Ladner, Hennie R. Hoogenboom, Simon E. Hufton, Affinity maturation of Fab antibody fragments by fluorescent-activated cell sorting of yeast-displayed libraries FEBS Letters. ,vol. 546, pp. 288- 294 ,(2003) , 10.1016/S0014-5793(03)00602-1
E. T. Boder, K. S. Midelfort, K. D. Wittrup, Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity Proceedings of the National Academy of Sciences. ,vol. 97, pp. 10701- 10705 ,(2000) , 10.1073/PNAS.170297297
B. R. Harvey, G. Georgiou, A. Hayhurst, K. J. Jeong, B. L. Iverson, G. K. Rogers, Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 9193- 9198 ,(2004) , 10.1073/PNAS.0400187101
Tai Te Wu, From esoteric theory to therapeutic antibodies. Applied Biochemistry and Biotechnology. ,vol. 47, pp. 107- 118 ,(1994) , 10.1007/BF02787928
Mitchell Ho, Robert J. Kreitman, Masanori Onda, Ira Pastan, In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin. Journal of Biological Chemistry. ,vol. 280, pp. 607- 617 ,(2005) , 10.1074/JBC.M409783200
William J. Checovich, Randall E. Bolger, Thomas Burke, Fluorescence polarization - a new tool for cell and molecular biology Nature. ,vol. 375, pp. 254- 256 ,(1995) , 10.1038/375254A0
Andrew D Griffiths, Dan S Tawfik, Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization The EMBO Journal. ,vol. 22, pp. 24- 35 ,(2003) , 10.1093/EMBOJ/CDG014