Reaction of 2-hydroxy- N ′-[(4-oxo-4 H -chromen-3-yl)methylidene]benzohydrazide with some phosphorus reagents. Synthesis and evaluation of anticancer activity of novel α-hydrazinophosphonic acid, 1,4,5,2λ 5 -oxadiazaphosphinines, and 1,3,2λ 5 -benzoxazaphosphinines bearing a chromone ring
作者： T. E. Ali , M. M. Ali , S. M. Abdel-Kariem , M. M. Ahmed
DOI: 10.1134/S107042801706015X
关键词: Reagent 、 Breast cancer cells 、 Cancer cell lines 、 Stereochemistry 、 Phosphorus 、 Chemistry 、 Chromone 、 VEGF receptors 、 Ring (chemistry)
摘要: Novel 1,4,5,2-Oxadiazaphosphinines, 1,3,2-benzoxazaphosphinines, and α-hydrazinophosphonic acid bearing a chromone ring were obtained by reactions of 2-hydroxy-N′-[(4-oxo-4H-chromen-3-yl)-methylidene]benzohydrazide with some phosphorus reagents such as phosphonic its esters, sulfides, halides. The synthesized compounds evaluated for their anticancer activity against four cancer cell lines. Two exhibited high effects MCF-7 breast cells on the expression VEGF inhibition.
springer.com
sci-hub.se 参考文章(28)
S. V. Nicosia, R. F. Nicosia, M. Smith, Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. American Journal of Pathology. ,vol. 145, pp. 1023- 1029 ,(1994)
Raphael E. Pollock, Aiqing Lang, Dihua Yu, Lee M. Ellis, Lianglin Zhang, Mei Hu, Shunbin Xiong, Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Research. ,vol. 60, pp. 3655- 3661 ,(2000)
Abhijit S. Bhat, Jennifer L. Whetstone, Robert W. Brueggemeier, Novel synthetic routes suitable for constructing benzopyrone combinatorial libraries Tetrahedron Letters. ,vol. 40, pp. 2469- 2472 ,(1999) , 10.1016/S0040-4039(99)00279-8
Fatma Abdel-Fattah Ragab, Nehad Aboul Magd El-Sayed, Amal Abdel Haleem Mohamed Eissa, Ahmed Mahmoud El Kerdawy, Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. Chemical & Pharmaceutical Bulletin. ,vol. 58, pp. 1148- 1156 ,(2010) , 10.1248/CPB.58.1148
Masaichi Hasegawa, Naohiko Nishigaki, Yoshiaki Washio, Kazuya Kano, Philip A. Harris, Hideyuki Sato, Ichiro Mori, Rob I. West, Megumi Shibahara, Hiroko Toyoda, Liping Wang, Robert T. Nolte, James M. Veal, Mui Cheung, Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors. Journal of Medicinal Chemistry. ,vol. 50, pp. 4453- 4470 ,(2007) , 10.1021/JM0611051
Hafez M. El-Shaaer, Pavlína Foltínová, Margita Lácová, Jarmila Chovancová, Henrieta Stankovičová, Synthesis, antimicrobial activity and bleaching effect of some reaction products of 4-oxo-4H-benzopyran-3-carboxaldehydes with aminobenzothiazoles and hydrazides Farmaco. ,vol. 53, pp. 224- 232 ,(1998) , 10.1016/S0014-827X(98)00015-9
D B Rifkin, D Moscatelli, Recent developments in the cell biology of basic fibroblast growth factor. Journal of Cell Biology. ,vol. 109, pp. 1- 6 ,(1989) , 10.1083/JCB.109.1.1
Kyoko Kawasaki, Tetsuro Watabe, Hitoshi Sase, Masanori Hirashima, Hiroshi Koide, Yasuyuki Morishita, Keiko Yuki, Toshikuni Sasaoka, Toshio Suda, Motoya Katsuki, Kohei Miyazono, Keiji Miyazawa, Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells. Journal of Cell Biology. ,vol. 181, pp. 131- 141 ,(2008) , 10.1083/JCB.200709127
Christopher J. Bennett, Stuart T. Caldwell, Donald B. McPhail, Philip C. Morrice, Garry G. Duthie, Richard C. Hartley, Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorganic & Medicinal Chemistry. ,vol. 12, pp. 2079- 2098 ,(2004) , 10.1016/J.BMC.2004.02.031
Tarik El-Sayed Ali, Synthesis and antibacterial activity of some new thiadiaza/triazaphospholes, thiadiaza/triaza/tetrazaphosphinines and thiadiaza/tetrazaphosphepines containing 1,2,4-triazinone moiety European Journal of Medicinal Chemistry. ,vol. 44, pp. 4539- 4546 ,(2009) , 10.1016/J.EJMECH.2009.06.022