The in vivo immunomodulatory and synergistic anti-tumor activity of thymosin α1–thymopentin fusion peptide and its binding to TLR2
作者： Juan Li , Yanna Cheng , Xinke Zhang , Lei Zheng , Zhen Han
DOI: 10.1016/J.CANLET.2013.05.006
关键词: Pharmacology 、 Surface plasmon resonance 、 Biochemistry 、 Receptor 、 Thymosin 、 Plasma protein binding 、 Thymopentin 、 Interferon gamma 、 TLR2 、 In vivo 、 Chemistry 、 Cancer research 、 Oncology
摘要: In the present study, immunomodulatory and synergistic anti-tumor activity of thymosin α1-thymopentin fusion peptide (Tα1-TP5) was investigated in vivo. addition, potential receptor Tα1-TP5 by surface plasmon resonance (SPR) binding studies. It found that (305 μg/kg) alleviated immunosuppression induced hydrocortisone (HC). combined with cyclophosphamide (CY) had a better tumor growth inhibitory effect than CY alone. Furthermore, higher affinity (KD=6.84 μmol/L) to toll-like 2 (TLR2) Tα1 (K(D)=35.4 μmol/L), but its not significantly different from TP5. The results our work indicate can possibly be developed as new agent.
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