Small-bowel infarction from disseminated aspergillosis.

作者: Christophe Trésallet , Quang Nguyen-Thanh , Marie-Hélène Aubriot-Lorton , Jean-Paul Akakpo , Ahmad Al Jijakli

DOI: 10.1007/S10350-004-0625-9

关键词: Acute abdomenMycosisColonoscopyAspergillus fumigatusAnastomosisBowel infarctionAspergillosisMedicineSurgeryRadiologyAbdominal pain

摘要: Despite the use of new, effective drugs, disseminated invasive aspergillosis often remains lethal in neutropenic patients. Diagnosis is difficult because early symptoms are nonspecific. New tools could help diagnosis and lead to surgery when needed. A patient developed an acute abdomen. CT findings were a diffuse, small-bowel distention with thickened, distal, ileum wall. Emergency was performed resection immediate anastomosis distal ileum. Pathology small bowel showed wall necrosis invasion by Aspergillus fumigatus. The postoperative course uneventful except for persisting diarrhea secondary coexistent infection Clostridium difficile. antigene serum positive, whereas neither pulmonary nor central nervous system observed on scan. This should be considered patients show abdominal pain fever. Repetition antigenemia, search others localizations, scan, colonoscopy biopsies until allows administration antifungal therapy.

参考文章(13)
B.J. Kullberg, A.M.L. Oude Lashof, Epidemiology of opportunistic invasive mycoses. European Journal of Medical Research. ,vol. 7, pp. 183- 191 ,(2002)
David W. Denning, David A. Stevens, Antifungal and Surgical Treatment of Invasive Aspergillosis: Review of 2,121 Published Cases Clinical Infectious Diseases. ,vol. 12, pp. 1147- 1201 ,(1990) , 10.1093/CLINIDS/12.6.1147
AB Sousa, G Ferreira, J Veiga, A Carvalho, Bowel infarction due to aspergillosis The Lancet. ,vol. 359, pp. 210- ,(2002) , 10.1016/S0140-6736(02)07446-9
J. S. Sartin, M. P. Wilhelm, M. R. Keating, K. Batts, R. A. F. Krom, A case OF Aspergillus fumigatus peritonitis complicating liver transplantation European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 13, pp. 25- 28 ,(1994) , 10.1007/BF02026119
W.F. Marterre, Alan T. Mong, Andrew R. Pulito, Locally invasive aspergillosis of the bowel. Journal of Pediatric Surgery. ,vol. 27, pp. 1611- 1613 ,(1992) , 10.1016/0022-3468(92)90527-E
Najib Safieddine, Brian M Taylor, C.M Guiraurdon, Small bowel infarction secondary to aspergillosis in a post-cardiac transplant patient: a case report. Journal of Heart and Lung Transplantation. ,vol. 21, pp. 935- 937 ,(2002) , 10.1016/S1053-2498(02)00394-7
R J Prescott, M Harris, S S Banerjee, Fungal infections of the small and large intestine. Journal of Clinical Pathology. ,vol. 45, pp. 806- 811 ,(1992) , 10.1136/JCP.45.9.806
S S Shah, B A Birnbaum, J E Jacobs, Disseminated aspergillosis inciting intestinal ischaemia and obstruction British Journal of Radiology. ,vol. 74, pp. 1145- 1147 ,(2001) , 10.1259/BJR.74.888.741145
Rubin Cohen, John E. Heffner, Bowel infarction as the initial manifestation of disseminated aspergillosis. Chest. ,vol. 101, pp. 877- 879 ,(1992) , 10.1378/CHEST.101.3.877