Implications of Intrahepatic Cholangiocarcinoma Etiology on Recurrence and Prognosis after Curative-Intent Resection: a Multi-Institutional Study

摘要: We sought to investigate the prognosis of patients following curative-intent surgery for intrahepatic cholangiocarcinoma (ICC) stratified by hepatitis B (HBV-ICC), hepatolithiasis (Stone-ICC), and no identifiable cause (conventional ICC) etiologic subtype. 986 with HBV-ICC (n = 201), stone-ICC (n = 103), conventional ICC (n = 682) who underwent resection were identified from a multi-institutional database. Propensity score matching (PSM) was used mitigate residual bias. more often had cirrhosis, earlier stage tumors, mass-forming lesion, well-to-moderate tumor differentiation, an R0 versus or patients. Five-year recurrence-free survival among 23.9 17.8%, respectively, only 8.3% stone-ICC. Similarly, 5-year overall 18.3% compared 48.9 38.0% ICC, respectively. On PSM, group equivalent long-term outcomes as In contrast, on median 18.0 months 44.0 months ICC. Median after intrahepatic-only recurrence (6.0 months) worse than OS (13.0 months) (12.0 months) (p = 0.006 p = 0.082, respectively). While better unadjusted analyses, these differences mitigated PSM suggesting stage-for-stage in outcomes. These data highlight relative importance etiology established clinicopathological factors