Experimental implication of celiac ganglionotropic invasion of pancreatic‐cancer cells bearing c‐ret proto‐oncogene with reference to glial‐cell‐line‐derived neurotrophic factor (GDNF)
作者： Yuji Okada, , Hiromitsu Takeyama , Mikinori Sato , Masayuki Morikawa , Kazuya Sobue
DOI: 10.1002/(SICI)1097-0215(19990331)81:1<67::AID-IJC13>3.0.CO;2-V
关键词: Cancer research 、 Glial cell line-derived neurotrophic factor 、 Perineural invasion 、 Neurotrophic factors 、 Biology 、 GDNF family of ligands 、 Cancer 、 Internal medicine 、 Endocrinology 、 Oncogene 、 Pancreatic cancer 、 Pancreas
摘要: Perineural invasion is a prominent clinical feature of pancreatic cancer which causes difficulty in curative resection. In the present study, human cell lines, PaCa-2, AsPC-1, SW1990 and Capan-2, were all found to express abundant c-ret proto-oncogene mRNA RET protein, member receptor-tyrosine-kinase superfamily, identified as being receptor for glial-cell-line-derived neurotrophic factor (GDNF). an assay, migration cells was markedly induced by co-cultivation with glioma cells, T98G or A172, capable producing secreting GDNF. Anti-GDNF antibody conditioned media suppressed much migratory activity. Checkerboard analysis showed both chemotactic chemokinetic activity There no detectable expression another GDNF component, glycosyl-phosphatidylinositol-linked (GFRα-1), pancreatic-cancer suggesting that neural spreads along concentration gradient produced from peripheral ganglions through direct interaction its receptor, product. Immunochemical localization celiac ganglionic tissue supported this contention. Int. J. Cancer 81:67–73, 1999. © 1999 Wiley-Liss, Inc.
sci-hub.se 参考文章(20)
Y Buma, M Takahashi, T Iwamoto, Y Inaguma, H Hiai, H Ikeda, Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. ,vol. 3, pp. 571- 578 ,(1988)
A. Karameris, P. Kanavaros, D. Aninos, V. Gorgoulis, G. Mikou, Th. Rokas, M. Niotis, N. Kalogeropoulos, Expression of Epidermal Growth Factor (EGF) and Epidermal Growth Factor Receptor (EGFR) in Gastric and Colorectal Carcinomas1 Pathology Research and Practice. ,vol. 189, pp. 133- 137 ,(1993) , 10.1016/S0344-0338(11)80082-8
H K Kleinman, A Albini, G R Martin, S A Aaronson, Y Iwamoto, R N McEwan, J M Kozlowski, A Rapid in Vitro Assay for Quantitating the Invasive Potential of Tumor Cells Cancer Research. ,vol. 47, pp. 3239- 3245 ,(1987)
N Tanigawa, H Amaya, M Matsumura, T Shimomatsuya, Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma. Journal of Clinical Oncology. ,vol. 15, pp. 826- 832 ,(1997) , 10.1200/JCO.1997.15.2.826
Clemens Suter-Crazzolara, Klaus Unsicker, GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells Molecular Brain Research. ,vol. 41, pp. 175- 182 ,(1996) , 10.1016/0169-328X(96)00089-7
Klaus D Beck, Ian Irwin, Janet Valverde, Thomas J Brennan, J.William Langston, Franz Hefti, GDNF Induces a Dystonia-like State in Neonatal Rats and Stimulates Dopamine and Serotonin Synthesis Neuron. ,vol. 16, pp. 665- 673 ,(1996) , 10.1016/S0896-6273(00)80085-9
VE Koliatsos and A Rosenthal CE Henderson, HS Phillips, RA Pollock, AM Davies, C Lemeulle, M Armanini, LC Simpson, B Moffet, RA Vandlen, None, GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle Science. ,vol. 266, pp. 1062- 1064 ,(1994) , 10.1126/SCIENCE.7973664
Pascale Durbec, Camelia V. Marcos-Gutierrez, Carol Kilkenny, Maria Grigoriou, Kirmo Wartiowaara, Petro Suvanto, Darrin Smith, Bruce Ponder, Frank Costantini, Mart Saarma, Hannu Sariola, Vassilis Pachnis, GDNF signalling through the Ret receptor tyrosine kinase Nature. ,vol. 381, pp. 789- 793 ,(1996) , 10.1038/381789A0
Masahide Takahashi, Jerome Ritz, Geoffrey M. Cooper, Activation of a novel human transforming gene, ret, by DNA rearrangement Cell. ,vol. 42, pp. 581- 588 ,(1985) , 10.1016/0092-8674(85)90115-1
Shuqian Jing, Duanzhi Wen, Yanbin Yu, Paige L Holst, Yi Luo, Mei Fang, Rami Tamir, Laarni Antonio, Zheng Hu, Rod Cupples, Jean-Claude Louis, Sylvia Hu, Bruce W Altrock, Gary M Fox, GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF Cell. ,vol. 85, pp. 1113- 1124 ,(1996) , 10.1016/S0092-8674(00)81311-2