Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes
作者： Tom Rubin , Theodore von Haimberger , Alexander Helmke , Johan Lock , Martin Stockmann
关键词: Breath test 、 Liver therapy 、 Absorption (pharmacology) 、 Liver metabolism 、 Nuclear magnetic resonance 、 Liver tumor 、 Time windows 、 Status assessment 、 Chemistry 、 Drug metabolism
摘要: The actual metabolic capacity of the liver is crucial for disease identification, therapy, and tumor resection. By combining induced drug metabolism high sensitivity IR spectroscopy exhaled air, we provide a method quantitative assessment at bedside within 20 to 60 min. Fast administration 13C-labelled methacetin induces fast response tracked in real-time by increase 13CO2 air. concentration air allows determination (LiMAx-test). Fluctuations CO2 concentration, pressure temperature are minimized special gas handling, tracking several spectrally resolved absorption bands with quantum cascade laser. Absorption measurement different 12CO2 rotation-vibration transitions same time window multiple referencing reduction systematic errors. This FLIP (Fast investigation package) setup being successfully used plan operations determine status patients.
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