作者: Baotian Zhao , Wenhan Hu , Yanshan Ma , Jianguo Zhang , Xiu Wang
DOI: 10.21037/QIMS-20-624
关键词: Endocrinology 、 Internal medicine 、 Electroencephalography 、 Hippocampal sclerosis 、 Quantitative assessment 、 Amygdala 、 Magnetic resonance imaging 、 Temporal lobe 、 Epilepsy 、 Hippocampus 、 Medicine
摘要: Background Magnetic resonance imaging (MRI) changes in hippocampal sclerosis (HS) could be subtle a significant proportion of mesial temporal lobe epilepsy (mTLE) patients. In this study, we aimed to document the structural and functional hippocampus amygdala seen HS Methods Quantitative features were extracted from MRI data 66 mTLE patients 28 controls. Structural covariance analysis was undertaken using volumetric hippocampus. Functional connectivity (FC) measured resting intracranial electroencephalography (EEG) analyzed 22 16 non-HS disease Results Hippocampal atrophy present both MRI-positive MRI-negative groups (Mann-Whitney U: 7.61, P<0.01; Mann-Whitney 6.51, P<0.01). Amygdala volumes decreased patient group 2.92, P<0.05), especially 2.75, P<0.05). The showed normalized tightly coupled controls (ρSpearman =0.72, FC indicated that had significantly increased (Student's t: 2.58, P=0.03) within but between 3.33, P=0.01), particularly for Conclusions changes, including pole blurring, are patients, suggesting potential usefulness incorporating quantitative analyses into clinical practice. is characterized by intra-hippocampal EEG synchronization coupling amygdala.