Korean medicinal plant extracts exhibit antiviral potency against viral hepatitis.

摘要: Objectives Investigation of natural ethnopharmacologic extracts exhibiting antiviral potential may lead to the discovery new therapeutics for treatment chronic viral hepatitis infections. Traditional Korean medicinal herbs have been identified that exhibit potency against B virus (HBV) and C (HCV) Research on naturally derived is facilitated through use appropriate animal liver cell culture models these hepatotrophic pathogens. this study were demonstrate activity an aqueous extract herbal formulation KYH-1 in surrogate vitro assays HBV HCV identify mechanisms action. Methods Antiviral was measured tissue systems support replication woodchuck (WHV), bovine diarrhea (BVDV). These serve as HCV, respectively. A recombinant polymerase gene expression assay used define a molecular target. Results exhibited potent WHV lesser extent BVDV. its constituent components inhibited priming vitro. Additionally, suppressed human hepatoblastoma line. Conclusion Evaluation products standardized provides scientific basis complementary or alternative medicines. This significant results justifying preclinical evaluation therapy