Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer.

作者: Horacio Cabral , Yuan Huang , Peng Mi , Jing Liu , Xixi Ai

DOI: 10.1016/J.BIOMATERIALS.2021.120847

关键词: Breast cancerCancer cellCancerRadiation therapyCancer researchImmunogenic cell deathMetastasisTumor hypoxiaImmunotherapyMedicine

摘要: … developed novel tumor-targeted polymeric micelles sensing hypoxia in tumors to activate … for effectively eradicating advanced breast cancer. The hypoxia-activatable polymeric micelles …

参考文章(55)
Ira Mellman, Ralph M. Steinman, Dendritic cells: specialized and regulated antigen processing machines. Cell. ,vol. 106, pp. 255- 258 ,(2001) , 10.1016/S0092-8674(01)00449-4
Adrian L. Harris, Hypoxia — a key regulatory factor in tumour growth Nature Reviews Cancer. ,vol. 2, pp. 38- 47 ,(2002) , 10.1038/NRC704
Chang W. Song, Effect of Local Hyperthermia on Blood Flow and Microenvironment: A Review Cancer Research. ,vol. 44, ,(1984)
Zi-Fen Su, Xiuguo Zhang, James R. Ballinger, A. M. Rauth, Alfred Pollak, John R. Thornback, Synthesis and evaluation of two technetium-99m-labeled peptidic 2-nitroimidazoles for imaging hypoxia. Bioconjugate Chemistry. ,vol. 10, pp. 897- 904 ,(1999) , 10.1021/BC9900542
A. J. Rech, R. Mick, S. Martin, A. Recio, N. A. Aqui, D. J. Powell, T. A. Colligon, J. A. Trosko, L. I. Leinbach, C. H. Pletcher, C. K. Tweed, A. DeMichele, K. R. Fox, S. M. Domchek, J. L. Riley, R. H. Vonderheide, CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients Science Translational Medicine. ,vol. 4, ,(2012) , 10.1126/SCITRANSLMED.3003330
Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kaori Machitani, Arnida, Yu Matsumoto, Makoto Oba, Kanjiro Miyata, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka, Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer Nature Communications. ,vol. 5, pp. 3545- ,(2014) , 10.1038/NCOMMS4545
Patricia S Steeg, Tumor metastasis: mechanistic insights and clinical challenges Nature Medicine. ,vol. 12, pp. 895- 904 ,(2006) , 10.1038/NM1469
LISA J. FREDERIKSEN, D. ROBERT SIEMENS, JEREMY P. HEATON, LORI R. MAXWELL, MICHAEL A. ADAMS, CHARLES H. GRAHAM, Hypoxia Induced Resistance to Doxorubicin in Prostate Cancer Cells is Inhibited by Low Concentrations of Glyceryl Trinitrate The Journal of Urology. ,vol. 170, pp. 1003- 1007 ,(2003) , 10.1097/01.JU.0000081126.71235.E0
Kirsten Sanna, Einar K. Rofstad, Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro. International Journal of Cancer. ,vol. 58, pp. 258- 262 ,(1994) , 10.1002/IJC.2910580219
Victor H. Fingar, T.Jeffery Wieman, Yong Joon Park, Barbara W. Henderson, Implications of a pre-existing tumor hypoxic fraction on photodynamic therapy Journal of Surgical Research. ,vol. 53, pp. 524- 528 ,(1992) , 10.1016/0022-4804(92)90101-5