How is membrane phospholipid biosynthesis controlled in neural tissues

摘要: Phospholipids are the major constituents of cell membranes, and have numerous structural functional roles in nervous system. Although metabolic pathways responsible for syntheses phosphatides phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer) well understood, mechanisms controlling these neural tissue not been fully characterized. Recent studies suggested that main factors PtdCho PtdEtn synthesis by Kennedy cycle tend to be intracellular levels key substrates biosynthetic enzymes, or changes activities rate-limiting enzymes. Moreover, different control may operate, depending upon state tissue.